Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Diiodotyrosine, used by the thyroid hormones T4 and T3, Diiodotyrosine may help the thyroid gland to maintain proper function and help preserve lean muscle and supports the thyroid without suppressing TSH levels.

Evodiamine is a chemical that is extracted from a particular species of plants that has been shown to reduce overall fat intake.

Green Tea Extract- By increasing the body's metabolism, it is widely believed that green tea extract largely aids in weight loss.

Iodotyrosone, which is a form of tyrosine with iodine added.

L-Tyrosine is an amino acid that is nonessential. It is synthesized from the body from phenylalanine which is also an amino acid. L-Tyrosine has the power to have an effect on the neurotransmitters and this affects various health conditions including depression, mood disorders and Parkinson’s disease. Many such studies have proved that L-Tyrosine helps people having depression. It acts as a precursor and eases the effects of psychosocial, environmental and physical stress. L-Tyrosine turns into melanin by the skin cells and the dark pigment prevents the ultraviolet light from affecting. The thyroid hormones playing a significant role in the process of the body also contain tyrosine. L-Tyrosine is commonly found in all the dairy products, fish, oats, wheat, meat and also in all other protein containing foods. This is also found to be beneficial for people trying to withdraw alcohol. L-Tyrosine has not exhibited severe side effects, yet taking it should be recommended by doctors.

Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It occurs naturally in all citrus fruits so it is also called citrus Naringin. It is used in medicine for its pharmacological effects such as an antioxidant and for blood lipid lowering. Research also shows that Naringin can be used for inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2. Its anti-cancer effects are also being studied by researchers. Naringin is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated to make naringin dihydrochalcone, which is used as a sugar-free sweetener 300 times sweater then sugar.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Synephrine, More commonly called "bitter orange" or Citrus Aurantium, which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Yerba Matte has a level of caffeine and is therefore a stimulant aids in toning, balancing and strengthening the body, aids in digestion, calms and balances nerves and is also used to help treat allergies and sinusitis.