Caffeine is the most widely used legal stimulant of the central nervous system and is also used in D4 Extreme Weight Loss, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Clary Sage Powder, also known as Salvia sclarea, is basically a biennial herb. It is a herb native throughout Europe and central and east Asia. Though, it was historically found in France, Switzerland, Italy and Syria. It reaches a height of one meter at the time of maturity. It has wooly texture leaves. The flowers on this herb appear in clusters on its stem and are often of the color pink, white or pale purple. Salvia sclarea is known to have an odor that appeals to some while at the same time are very unpleasant for the others. Majority of the salvia sclarea cultivation is done for the perfume industry in England, France and southern Russia. A lot specialty stores and scent shops sell the distilled essential oil obtained from salvia sclarea.

Evodia Rutaecarpa is a red color small fruit and this plant is found in Korea and northern china. It is cultivated in many places as ornamental landscaping plant. Evodia Rutaecarpa refers to a deciduous tree with woodlands and has shiny leaves with white flowers and small clusters. This fruit is used in healing. This fruit looks red in August and turns black in November. This is useful for medicines when it is the unripe stage. It can be used dried or fresh. Evodia Rutaecarpa fruit has a warm nature and is slightly toxic in taste. However, the fruit has good fragrance. Evodia Rutaecarpa extract or fruit is good to treat abdominal distress and this comprises of vomiting, nausea and diarrhea. It treats the morning diarrhea and stimulates the appetite. The interest in food that is lacking is also cured. Evodia is used as painkiller for headaches associated with vomiting and nausea.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Passion Flower- Passion vines, or Passiflora, are a 500 species strong genus of flowering plants that all belong to the family of Passifloraceae. While most of the plants are classified as vines, there are also some shrubs and herbaceous plants that can be found. With the exception of Europe and Africa, as well as Antarctica, these plants are found all over the rest of the world. While the passion flower is mostly known for the Maracuja, or Passiflora edulis, the passion fruit, the vines of some species in this genus are known to have properties that have been used by Native Americans for treatment of insomnia, epilepsy and hysteria, as noted with Passiflora incarnata. Many other species contain beta carboline harmala alkaloids, which function as monoamine oxidase inhibitors and are powerful antidepressants.

White Willow Bark is used as an anti-inflammatory and treats pains such as joint pain, flu, fever, back pain and osteoarthritis.