2-Methylpropionate is a vitamin-B derivative also called thiamine disulfide. It is used in medicine for treatment of asthenia (weakness, loss of appetite and inability to concentrate). It is used as supplement by bodybuilders and athletes because it is believed to increase physical resistance to fatigue, improve neuromuscular efficiency, learning and memory, and improve metabolic function of the cerebral cortex. Some users have also reported improved sleep patterns after use of 2-methylpropionate supplements. Research shows that it improves energy levels by increasing choline uptake by hippocampal neurons, thus resulting in an increase in synthesis and release of acetylcholine. Its effects on brain are because it increases neuronal membrane permeability.

Caffeine, a central nervous system stimulant used in Biotest Spike as an aid to stay awake, for mental alertness due to fatigue or, in combination with other ingredients for pain relief, and as a power and energy accelerate. Caffeine is available alone as a non-prescription drug over the counter medication, in combination with other non-prescription drugs, and in prescription drug combinations for relief of pain and headache. Like Ephedra, caffeine acts to increase mental alertness while providing additional energy for weight loss and exercise training. Caffeine is more than a stimulant as it goes deep into muscles to provide long lasting power while delaying the onset of muscle fatigue. Also great before working out, caffeine fights fatigue and helps you get ready for your workout. For dieters feeling sluggish that need just a little something extra to get them through the day, caffeine is the obvious no-calorie stimulant solution. Many products containing caffeine anhydrous contain as much caffeine as one or two cups of coffee. It is recommended to limit the use of caffeine containing medications, foods, or beverages while taking caffeine supplements as excess caffeine intake may cause nervousness, irritability, sleeplessness and occasional rapid heart beat.

Guarana Extract is the extract of the guarana plant. It contains a significant amount of guaranine, a substance that is similar to caffeine found in coffee beans. It helps stimulate the adrenal glands and increase the production and release of hormones such as epinephrine, norepinephrine (adrenaline), and dopamine. This helps the metabolism of the body that enhances fat loss, and increases energy and endurance. It helps the body burn the fats to be used for energy. It aids in fighting stress, weakness and fatigue. As a stimulant, it also improves mental alertness, clarity, focus, concentration, and memory retention. Guarana also also improves the libido or sex drive in both men and women. Guarana also contains tannins that help prevent diarrhea and soothes the digestive system.

Thiamine is a water-soluble vitamin with no known toxic effects if taken with other members of the vitamin B complex. Thiamine is essential to a strong appetite and to enable the body to use sugars and other carbohydrates.

Yohimbine HCL is a bark and is appropriate for sexual dysfunction. This is the best for erection problems as it has alkaloids. The alkaloids possess medicinal properties and are used in drugs. Yohimbine meant the chemical found on the Yohimbe bark. This belongs to the chemical family called alkaloids. Yohimbine effects are impressive. Yohimbine is used since many centuries for sexual enhancement. This bark is now sold in alkaloid concentrations such as 4%, 8% and so on up to 20%. The higher is the concentration, the more is the potent. There are companies promoting it for weight loss as well. Yohimbine HCL exhibits side effects in the form of anxiety. This bark is dangerous when consumed in excessive amounts. Higher oral doses create numerous side effects like high blood pressure, rapid heart rate and over stimulation. It also causes sleeplessness and insomnia in users. It is best to take this only after the consultation of a physician or should be taken in minimal quantities.