Caffeine is the most widely used legal stimulant of the central nervous system and is also used in Applied Nutriceuticals RPM, with characteristics that have been described as restoration of alertness and removing from drowsiness. Coffee, Tea, many soft drinks and energy drinks as well as nutrition supplements have this ingredient, which is a psychoactive substance, a xanthine alkaloid that can act as a adenosine receptor antagonist, as well as a phosphodiesterase inhibitor. Although regular use of caffeine seems to have nootropic effects, enhancing cognitive abilities, it also is known to provide long term effects on the nervous and cardiovascular system, like in one study it was proven that people with normal to low blood pressure have the possibility of developing a heart disease significantly reduced, as well as the chance of getting the Parkinson’s disease.

Cocao Extract demonstrates numerous health benefits. It is able to act as an antioxidant and counteract some of the cellular damage that may cause chronic illnesses like cancer and heart disease. It has also been shown to decrease blood pressure and better blood flow in humans. One cup of cocoa has about three times the antioxidants contained in a cup of green tea, another drink known for its health benefits. An active ingredient in cacao is theobromine, which is an appetite suppressant. It also works as a metabolic stimulant and, therefore, can assist in weight loss the way other other stimulants do.

Epimedium, also popularly known as horny goat weed is a genus of herbaceous perennials belonging to the family Berberidaceae. The plant is found to possess aphrodisiac properties. Legend has it that a Chinese goat herder observed and reported increased sexual activity in his heard after it consumed the plant, hence the name. Its active ingredient is icariin. This ingredient has been reported to have a number of effects on the body. It inhibits the degradation of cyclic guanosine mono phosphate cGMP by PDE5 in the blood vessels supplying the corpus cavernosum of the penis. cGMP is the activated form of GMP produced by the release of nitric oxide in the vessels and relaxes the smooth muscle tissue resulting in the improvement in blood flow and erection. It also acts to increase mental faculties.

Grape seed is the seeds of the ordinary grapes. They are used primarily because they have polyphenols recognized as anti oxidants. Research confirms numerous health benefits of grape seed extracts; they limit lipid oxidation, thus controlling high blood pressure and high cholesterol levels. Grape seeds contain phenolics, which are useful in treatment of heart disease because they inhibit platelet aggregation and reduce inflammation, however, the results are preliminary and more research is being done to confirm these facts. A polyphenol contained in grape seeds is resveratrol which may inhibit cancer cell growth and proliferation, and it may also be active against HIV by inhibiting expression and replication of the genome of the virus.

L-Arginine is a very important amino acid that is required by the body for a number of functions. One of the main functions of L-Arginine is its ability to rid the body of ammonia, which is a waste product. It is also used in the manufacture of nitric oxide, which helps to relax the blood vessels, thereby increasing the flow of blood and reducing the chances of a heart attack. It is advised that supplements of L-Arginine should not be administered following a heart attack for fear that it could possibly aggravate cardiac shock. L-Arginine is being used in treating people with erectile dysfunction, as it relaxes the blood vessels surrounding the penis. It is also used in treating migraine and blood pressure.

Naringenin is a flavanoid found naturally in grape fruit. Its chemical formula is C15H12O5 and Mol. Mass is 272.257 g/mol. Research shows that it has significant health benefits; it functions as an antioxidant, scavenges free radicals, promotes carbohydrate metabolism and improves immune system function. Studies also show that Naringenin reduces oxidative DNA damage in vitro and has inhibitory effect on cytochrome P450 isoform CYP1A2 which can change pharmacokinetics in a human host of several popular drugs in an adverse manner. It is also shown to be effective in treatment of hepatitis C and to lower the cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats that are given a high-cholesterol diet.

Theobromine- The bitter alkaloid found in chocolate is known as theobromine. It comes from the cacoa plant and is found in chocolate as well as chocolate free foods that are consist of theobromine. Theobromine belongs to the methylxanthine class of chemical compounds. It is found in the leaves of the tea plant, the kola or cola nut and acai berries. No bromine is present in theobromine, despite the name. The properties of theobromine are that it is souluble in water, is crystalline, is a bitter powder, is listed as white or colorless in color. It is considered a lesser homologue because it has a lesser effect to caffeine. Theobromine is the kind of isomer which belongs to paraxanthine and theophylline at the same time. It is basically a xanthine having two methyl groups.